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Clopidogrel

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Clopidogrel

Clopidogrel is a medicine which is used as antiplatelet agent in various heart diseases. This drug prevents platelets to stick each other and avoid clot formation. This ability of it has helped doctors in successful use of Clopidogrel in cardiac treatments like stroke, heart attacks. Clopidogrel drug is metabolized by a gene known as CYP2C19, an enzyme produced by this gene involves in formation as well as breakdown of Clopidogrel drug. Variants of this gene have shown altered metabolism of drugs. Alleles 2*, 3* and 17* are considered to be responsible for poor and increased conversion of clopidogrel to its active metabolite. Allele 2* and 3* are known non-functional alleles and have shown reduced metabolism and hence poor response to clopidogrel treatment.
 

On the other side Allele 17* have proven increased response towards Clopidogrel drug activity. This allele is considered as functional and has shown higher response of platelets to clopidogrel.

USE OF TEST:

Clopidogrel use can cause serious or fetal bleeding if randomly prescribed. So the genotyping of CYP2C19 in clopidogrel treatment has hypothesized benefit of identifying drug response prior to the actual treatment. And also helped patients in precise and effective drug dosing.

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