CYP2D6

Cytochrome P450 2D6 (CYP2D6) is involved in metabolism of approximately 20% of commonly used drugs in varied fields such as psychiatry, oncology and cardiology. CYP2D6 is a highly polymorphic with single-nucleotide polymorphisms (SNPs), small insertions and deletions as well as larger structural variants including multiplications, deletions and hybridisations. The frequency of these variants changes across populations, while significantly affecting the drug-metabolizing enzymatic function of CYP2D6. Altered CYP2D6 function has been associated with both adverse drug reactions and reduced drug efficacy, and there is growing recognition of the clinical and economic burdens associated with suboptimal drug utilization in the patients.

Contract research organizations have to cater to new categories of emerging biologics and gene and cell therapies to stay cutting age in their spectrum of services. To help you keep pace and provide required support we offer in-house custom assay design and biomarker development assistance to ensure the right genes and variants are tested. geneOmbio Technologies has a large clinically validated menu with single genes and preconfigured panels and it can employ various technological platforms for genotyping right from Sanger sequencing till Taqman SNP genotyping.